Bcl-w expression in colorectal adenocarcinoma.
Wilson, James W Nostro, M C Balzi, Manuela Faraoni, P Cianchi, F Becciolini, Aldo Potten, Christopher S
Wilson, James W
Nostro, M C
Balzi, Manuela
Faraoni, P
Cianchi, F
Becciolini, Aldo
Potten, Christopher S
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Abstract
We have found that the anti-apoptotic Bcl-2 family protein, Bcl-w, was frequently expressed in colorectal adenocarcinomas, with 69/75 showing positive staining with anti-Bcl-w IgG. Adenomas demonstrated a much lower frequency of Bcl-w expression (only 1 of 17), as did adenocarcinomas from other epithelial tissues such as breast (0/8), stomach (1112) and cervix (0/12). Bcl-w status could be related to the histopathological classification of the tumours, with TNM stage III tumours showing significantly higher levels of expression than tumours of better prognostic grade (at P = 0.009). Those patients with node involvement also had tumours with significantly elevated levels of Bcl-w (at P = 0.02), compared to those which were node-negative. The results suggest that Bcl-w could play a general role in the progression from adenoma to adenocarcinoma in the colorectal epithelium. Currently, more data are being collected to allow us to assess the importance of Bcl-w for disease progression and patient survival.
Description
Date
2000-01
Publisher
Collections
Keywords
Colonic Cancer
Cancer Proteins
Rectal Cancer
Tumour Suppressor Protein p53
Cancer Proteins
Rectal Cancer
Tumour Suppressor Protein p53
Type
Article
Citation
Bcl-w expression in colorectal adenocarcinoma. 2000, 82 (1):178-85 Br. J. Cancer