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Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides.
Woods, Julie A Hadfield, John A McGown, Alan T Fox, Brian W
Woods, Julie A
Hadfield, John A
McGown, Alan T
Fox, Brian W
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Abstract
Bis(2-bromo-4,5-dimethoxyphenyl)sulfide (5) and bis(2-bromo-4,5-dimethoxyphenyl) selenide (7) have been shown to block cells in the G2/M phase of the cell cycle, whereas the debromo (4,6) equivalents do not. The biobromoselenide (7) is cytotoxic to tumour cells in vitro and has been shown to increase the mitotic index of treated cells. These biological effects are consistent with disruption of the mitotic apparatus. This agent does not inhibit microtubule assembly in vitro, but does bind to tubulin. Molecular modelling of these structures indicates that their spatial and electronic structures may make an important contribution to the biological activity.
Description
Date
1993-11
Publisher
Collections
Keywords
Leukaemia P388
Ovarian Cancer
Cultured Tumour Cells
Ovarian Cancer
Cultured Tumour Cells
Type
Article
Citation
Bioactivity and molecular modelling of diphenylsulfides and diphenylselenides. 1993, 1 (5):333-40 Bioorg. Med. Chem.