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LSD1: biologic roles and therapeutic targeting.
Maiques-Diaz, Alba Somervaille, Tim C P
Maiques-Diaz, Alba
Somervaille, Tim C P
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Abstract
LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors. Here we summarize structural and biochemical knowledge of this important epigenetic regulator, with a particular emphasis on the functional and preclinical studies in oncology that have provided justification for the evaluation of tranylcypromine derivative LSD1 inhibitors in early phase clinical trials.
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2016-08
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LSD1: biologic roles and therapeutic targeting. 2016, 8 (8):1103-16 Epigenomics