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A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.
Komseli, E Pateras, I Krejsgaard, T Stawiski, K Rizou, S Polyzos, A Roumelioti, F Chiourea, M Mourkioti, I Paparouna, E
Komseli, E
Pateras, I
Krejsgaard, T
Stawiski, K
Rizou, S
Polyzos, A
Roumelioti, F
Chiourea, M
Mourkioti, I
Paparouna, E
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Abstract
Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for cancer to progress. Micro-RNAs, a subclass of regulatory, non-coding RNAs, participate in senescence regulation. At the subcellular level micro-RNAs, similar to proteins, have been shown to traffic between organelles influencing cellular behavior. The differential function of micro-RNAs relative to their subcellular localization and their role in senescence biology raises concurrent in situ analysis of coding and non-coding gene products in senescent cells as a necessity. However, technical challenges have rendered in situ co-detection unfeasible until now.
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2018-01-10
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A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence. 2018, 19 (1):37 BMC Genomics