Histopathological and ultrastructural study of carotid atherosclerotic plaques: a study of four cases
Yong-Xin, R. Xue-Bin, Z. Shu-Xu, D. Yongqiang, Z. Ying, L. Jing, L. Ying-Dai, G. Hong-Cai, S. Eyden, Brian P
Yong-Xin, R.
Xue-Bin, Z.
Shu-Xu, D.
Yongqiang, Z.
Ying, L.
Jing, L.
Ying-Dai, G.
Hong-Cai, S.
Eyden, Brian P
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Abstract
To clarify the characteristics and origin of the cellular components in atherosclerosis, carotid atherosclerotic plaques (CAPs) of four patients were studied by light microscopy using hematoxylin-eosin, Congo red and alpha-smooth-muscle actin stains, and by transmission electron microscopy of different regions of CAPs. By light microscopy, CAPs were composed of 1) a fibrous cap; 2) an atherosclerotic core presenting focal fibrosis, neovascularization, hemorrhage, necrosis, chondrification and ossification; and 3) a basal band composed of a hyperplasic pseudo-media and affected tunica media. Ultrastructurally, the CAPs contained a diversity of cells including fibroblasts, myofibroblasts, osteochondrocytes, vascular smooth-muscle cells, foam cells and other myoid cells characterized by varied features of the above mentioned cells. The results indicated that CAPs were derived from a proliferation of multipotential mesenchymal stem cells, leading to the presence of degenerated foam cells and lipid-laden cells.
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Date
2021
Publisher
Collections
Keywords
Type
Article
Citation
Yong-xin R, Xue-bin Z, Shu-xu D, Yongqiang Z, Ying L, Jing L, et al. Histopathological and ultrastructural study of carotid atherosclerotic plaques: a study of four cases. Ultrastructural Pathology. 2021 Aug 30;1–16.