The european particle therapy network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation
De Roeck, L. van der Weide, H. L. Eekers, D. B. P. Kramer, M. C. Alapetite, C. Blomstrand, M. Burnet, N. G. Calugaru, V. Coremans, I. E. M. Di Perri, D.
De Roeck, L.
van der Weide, H. L.
Eekers, D. B. P.
Kramer, M. C.
Alapetite, C.
Blomstrand, M.
Burnet, N. G.
Calugaru, V.
Coremans, I. E. M.
Di Perri, D.
Citations
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Abstract
Purpose Treatment-related toxicity after irradiation of brain tumours has been underreported in the literature. Furthermore, there is considerable heterogeneity on how and when toxicity is evaluated. The aim of this European Particle Network (EPTN) collaborative project is to develop recommendations for uniform follow-up and toxicity scoring of adult brain tumour patients treated with radiotherapy. Methods A Delphi method-based consensus was reached among 24 international radiation-oncology experts in the field of neuro-oncology concerning the toxicity endpoints, evaluation methods and time points. Results In this paper, we present a basic framework for consistent toxicity scoring and follow-up, using multiple levels of recommendation. Level I includes all recommendations that are considered minimum of care, whereas level II and III are optional evaluations in the advanced clinical or research setting, respectively. Per outcome domain, the clinical endpoints and evaluation methods per level are listed. Where relevant the organ at risk threshold doses for recommended referral to specific organ specialists are defined. Conclusion These consensus-based recommendations for follow-up will enable the collection of uniform toxicity data of brain tumour patients treated with radiotherapy. This will facilitate collaboration and further propel the research field of radiation-induced toxicities relevant for these patients. An online tool to implement this guideline in clinical practice is provided at www.cancerdata.org.
Authors
De Roeck, L.
van der Weide, H. L.
Eekers, D. B. P.
Kramer, M. C.
Alapetite, C.
Blomstrand, M.
Burnet, N. G.
Calugaru, V.
Coremans, I. E. M.
Di Perri, D.
Harrabi, S.
Iannalfi, A.
Klaver, Y. L. B.
Langendijk, J. A.
Romero, A. M.
Paulsen, F.
Roelofs, E.
de Ruysscher, D.
Timmermann, B.
Vitek, P.
Weber, D. C.
Whitfield, G. A.
Nyström, P. W.
Zindler, J.
Troost, E. G. C.
Lambrecht, M.
van der Weide, H. L.
Eekers, D. B. P.
Kramer, M. C.
Alapetite, C.
Blomstrand, M.
Burnet, N. G.
Calugaru, V.
Coremans, I. E. M.
Di Perri, D.
Harrabi, S.
Iannalfi, A.
Klaver, Y. L. B.
Langendijk, J. A.
Romero, A. M.
Paulsen, F.
Roelofs, E.
de Ruysscher, D.
Timmermann, B.
Vitek, P.
Weber, D. C.
Whitfield, G. A.
Nyström, P. W.
Zindler, J.
Troost, E. G. C.
Lambrecht, M.
Description
Date
2022
Publisher
Collections
Keywords
Type
Article
Citation
De Roeck L, van der Weide HL, Eekers DBP, Kramer MC, Alapetite C, Blomstrand M, et al. The European Particle Therapy Network (EPTN) consensus on the follow-up of adult patients with brain and skull base tumours treated with photon or proton irradiation. Vol. 168, Radiotherapy and Oncology. Elsevier BV; 2022. p. 241–9.