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So You Can Teach Old Fibroblasts New Tricks

Virós, Amaya
; 
Girotti, Maria Romina
; 
Marais, Richard
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Abstract
New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses β-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581-3. ©2016 AACR.
Authors
Virós, Amaya
Girotti, Maria Romina
Marais, Richard
Affiliation
Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom. Amaya.Viros@cruk.manchester.ac.ukMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United KingdomMolecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester, United Kingdom
Description
Date
2016
Publisher
Collections
All Paterson Institute for Cancer Research
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Type
Article
Citation
So You Can Teach Old Fibroblasts New Tricks. 2016, 6 (6):581-3 Cancer Discov
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Volume Title
URI
http://hdl.handle.net/10541/617037
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