Cellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3.
Burt, Deborah J Johnston, Diane Rinke de Wit, T Van den Elsen, P Stern, Peter L
Burt, Deborah J
Johnston, Diane
Rinke de Wit, T
Van den Elsen, P
Stern, Peter L
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Abstract
Jeg-3 choriocarcinoma cells express class-I MHC HLA-G and low levels of a novel HLA-C product. The functional significance of such novel MHC class-I expression in regard of the cellular immune response has been investigated. Jeg-3 cells are NK-insensitive, but susceptible to LAK cytotoxicity, some of which is mediated by T cells. No Jeg-3-specific CTL or proliferative responses could be generated in allogeneic responder PBMC from several different donors. There was no detectable xenogeneic recognition of Jeg-3 cells even when preceded by in vivo priming. Jeg-3 cells are able to suppress proliferative responses in humans and others species. This is not reproduced by conditioned medium from the Jeg-3 cells, but can be overridden by IL-2. The ability of the Jeg-3 choriocarcinoma (trophoblast) cells to suppress in the MLR may reflect the processes which are shared to enable the survival of the foetus in a semi-allogeneic mother or a tumour in its host. It is not clear whether there is any relationship between the unusual class-I-MHC expression by trophoblast and the putative regulatory properties of the latter.
Description
Date
1991
Publisher
Collections
Keywords
Cancer Transplantation
Type
Article
Citation
Cellular immune recognition of HLA-G-expressing choriocarcinoma cell line Jeg-3. 1991, 6:117-22 Int. J. Cancer Suppl.