Regressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall.
Menasce, Lia P Shanks, Jonathan H Howarth, V S Banerjee, Saumitra S
Menasce, Lia P
Shanks, Jonathan H
Howarth, V S
Banerjee, Saumitra S
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Abstract
We report 2 cases of partially regressed malignant melanoma in which the brisk lymphocytic response closely resembled mycosis fungoides in 1 case and nodular sclerosing Hodgkin lymphoma in the other. Striking epidermotropism was present in both cases. The lymphocytes were predominantly of T8 cytotoxic subtype, and oligoclonal T-cell expansion was detected in 1 of the cases. The scanty residual melanoma cells were highlighted with HMB45 and S100 protein. We highlight the features of regression in melanoma that may lead to an erroneous diagnosis of lymphoma and discuss the finding of oligoclonal T-cell expansion in regressed melanocytic lesions.
Description
Date
2005-07
Publisher
Collections
Keywords
Cancer Regression
Skin Cancer
Tumour Markers
Skin Cancer
Tumour Markers
Type
Article
Citation
Regressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall. 2005, 13 (3):281-4 Int. J. Surg. Pathol.