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ESMO consensus conference recommendations on the management of locoregional melanoma: the ESMO Guidelines Committee
Michielin, O. van Akkooi, ACJ Ascierto, P. A. Dummer, R. Robert, C. Arance, A. Blank, C. U. Sileni, V. C. Donia, M.
Michielin, O.
van Akkooi, ACJ
Ascierto, P. A.
Dummer, R.
Robert, C.
Arance, A.
Blank, C. U.
Sileni, V. C.
Donia, M.
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Abstract
The European Society for Medical Oncology (ESMO) held a consensus conference on melanoma on 5-7 September 2019 in Amsterdam, The Netherlands. The conference included a multidisciplinary panel of 32 leading experts in the management of melanoma. The aim of the conference was to develop recommendations on topics that are not covered in detail in the current ESMO Clinical Practice Guideline and where available evidence is either limited or conflicting. The main topics identified for discussion were: (i) the management of locoregional disease; (ii) targeted versus immunotherapies in the adjuvant setting; (iii) targeted versus immunotherapies for the first-line treatment of metastatic melanoma; (iv) when to stop immunotherapy or targeted therapy in the metastatic setting; and (v) systemic versus local treatment of brain metastases. The expert panel was divided into five working groups in order to each address questions relating to one of the five topics outlined above. Relevant scientific literature was reviewed in advance. Recommendations were developed by the working groups and then presented to the entire panel for further discussion and amendment before voting. This manuscript presents the results relating to the management of locoregional melanoma, including findings from the expert panel discussions, consensus recommendations and a summary of evidence supporting each recommendation. All participants approved the final manuscript.
Keywords: adjuvant; consensus; immunotherapy; melanoma; targeted therapy; treatment.
Authors
Michielin, O.
van Akkooi, ACJ
Lorigan, Paul C
Ascierto, P. A.
Dummer, R.
Robert, C.
Arance, A.
Blank, C. U.
Sileni, V. C.
Donia, M.
Faries, M. B.
Gaudy-Marqueste, C.
Gogas, H.
Grob, J. J.
Guckenberger, M.
Haanen, J.
Hayes, A. J.
Hoeller, C.
Lebb�, C.
Lugowska, I.
Mandal�, M.
Marquez-Rodas, I
Nathan, P.
Neyns, B.
Bagge, R. O.
Puig, S.
Rutkowski, P.
Schilling, B.
Sondak, V. K.
Tawbi, H.
Testori, A.
Keilholz, U.
van Akkooi, ACJ
Lorigan, Paul C
Ascierto, P. A.
Dummer, R.
Robert, C.
Arance, A.
Blank, C. U.
Sileni, V. C.
Donia, M.
Faries, M. B.
Gaudy-Marqueste, C.
Gogas, H.
Grob, J. J.
Guckenberger, M.
Haanen, J.
Hayes, A. J.
Hoeller, C.
Lebb�, C.
Lugowska, I.
Mandal�, M.
Marquez-Rodas, I
Nathan, P.
Neyns, B.
Bagge, R. O.
Puig, S.
Rutkowski, P.
Schilling, B.
Sondak, V. K.
Tawbi, H.
Testori, A.
Keilholz, U.
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Date
2020
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Article
Citation
Michielin O, van Akkooi A, Lorigan P, Ascierto PA, Dummer R, Robert C, et al. ESMO consensus conference recommendations on the management of locoregional melanoma: under the auspices of the ESMO Guidelines Committee. Ann Oncol. 2020.