Tumoural expression of connective tissue growth factor (CTGF) impacts on survival in patients diagnosed with hepatocellular carcinoma (HCC).
Lamarca, Angela Mendiola, M Bernal, E Heredia, V Díaz, E Miguel, M Pastrian, L Burgos, E Feliu, J Barriuso, J
Lamarca, Angela
Mendiola, M
Bernal, E
Heredia, V
Díaz, E
Miguel, M
Pastrian, L
Burgos, E
Feliu, J
Barriuso, J
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Abstract
Hepatocellular carcinoma (HCC) tends to develop in the liver when there is a high level of background inflammation (cirrhosis). Treatment options are limited and mainly based on systemic therapies such as anti-angiogenic drugs (e.g. sorafenib). Connective tissue growth factor (CTGF) is a matricellular protein involved in inflammation, tumour growth and angiogenesis. The aim of this study is to determine the expression of CTGF and hypoxia inducible factors (HIF) in HCC and to clarify its impact on relapse and survival.
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Date
2015
Publisher
Collections
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Type
Article
Citation
Tumoural expression of connective tissue growth factor (CTGF) impacts on survival in patients diagnosed with hepatocellular carcinoma (HCC). 2015, 15 (5):435-44 Curr Cancer Drug Targets