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RUNX transcription factors: orchestrators of development
Mevel, R Draper, JE Lie-A-Ling, Michael Kouskoff, Valerie Lacaud, Georges
Mevel, R
Draper, JE
Lie-A-Ling, Michael
Kouskoff, Valerie
Lacaud, Georges
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Abstract
RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.
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Date
2019
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Citation
Mevel R, Draper JE, Lie ALM, Kouskoff V, Lacaud G. RUNX transcription factors: orchestrators of development. Development. 2019 Sep 5;146(17).