Structure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones.
Hadfield, John A Pavlidis, V H McGown, Alan T Whitworth, C Perry, P J Fox, Brian W
Hadfield, John A
Pavlidis, V H
McGown, Alan T
Whitworth, C
Perry, P J
Fox, Brian W
Citations
Altmetric:
Abstract
Eight benzoxazin-4-ones related in structure to NSC 341964 (1) have been tested for cytotoxicity in two different cell systems. Two of the benzoxazin-4-ones (3 and 10) showed good cytotoxicity (ID50 = 9.9 and 8.9 microM) in P388 cells. The nitrobenzoxazin-4-one (10) caused a significant alteration in cell cycle distribution when administered to P388 cells and was an inhibitor of porcine pancreatic elastase. Structure-activity relationships are discussed.
Description
Date
1994-10
Publisher
Collections
Keywords
Cancer DNA
Antitumour Drug Screening Assays
Leukaemia P388
Cultured Tumour Cells
Antitumour Drug Screening Assays
Leukaemia P388
Cultured Tumour Cells
Type
Article
Citation
Structure-activity studies on 2-aryl-4H-3,1-benzoxazin-4-ones. 1994, 5 (5):533-8 Anticancer Drugs