The radiosensitivity of cultured human and mouse keratinocytes.
Parkinson, E Hume, W J Potten, Christopher S
Parkinson, E
Hume, W J
Potten, Christopher S
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Abstract
Clonogenic survival assays after gamma-radiation in vitro were performed on freshly isolated and subcultured keratinocytes from mouse skin, mouse tongue and human skin. Survival curves were constructed by fitting the data to a multi-target model of cell survival. When subcultured, keratinocytes from all sites produced survival curves which showed a reduced shoulder region and an increased D0 when compared with their freshly isolated counterparts. Freshly isolated human skin keratinocytes were more radiosensitive than mouse keratinocytes from either skin or tongue.
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Date
1986-10
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Article
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The radiosensitivity of cultured human and mouse keratinocytes. 1986, 50 (4):717-26 Int J Radiat Biol Rela Stud Phys Chem Med