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Development of Auer bodies from giant inclusions associated with rough endoplasmic reticulum in acute promyelocytic leukemia

Ru, Y. X.
; 
Dong, S. X.
; 
Liu, J.
; 
Eyden, Brian P
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Abstract
Giant inclusions and Auer bodies in promyeloblasts were investigated in a study which included transmission electron microscopy (TEM) for morphology and ultrastructural cytochemistry for myeloperoxidase in 10 patients with acute promyelocytic leukemia (APL). Ultrastructural cytochemistry demonstrated positive myeloperoxidase reactivity in giant inclusions, expanded rER cisternae, Auer bodies and primary granules. TEM revealed that giant inclusions were adorned by degenerated rER membrane, some of them sharing features with Auer bodies. We hypothesize a novel origin for Auer body development in promyeloblasts of APL, namely that they originate from peroxidase-positive and expanded rER cisternae, and that primary granules were directly released from these expanded rER elements, bypassing the Golgi apparatus.
Authors
Ru, Y. X.
Dong, S. X.
Liu, J.
Eyden, Brian P
Affiliation
State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of the Cell Ecosystem, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China
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Date
2023
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All Christie Publications
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Citation
Ru YX, Dong SX, Liu J, Eyden B. Development of Auer bodies from giant inclusions associated with rough endoplasmic reticulum in acute promyelocytic leukemia. Blood science (Baltimore, Md). 2023 Apr;5(2):111-7. PubMed PMID: 37228776. Pubmed Central PMCID: PMC10205345. Epub 2023/05/25. eng.
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http://hdl.handle.net/10541/626329
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