Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome.
Burt, E C McGown, Gail Thorncroft, Mary R James, Louise A Birch, Jillian M Varley, Jennifer
Burt, E C
McGown, Gail
Thorncroft, Mary R
James, Louise A
Birch, Jillian M
Varley, Jennifer
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Abstract
We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.
Description
Date
1999-04
Publisher
Collections
Keywords
Tumour Suppressor Genes
Tumour Suppressor Proteins
Tumour Suppressor Proteins
Type
Article
Citation
Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome. 1999, 80 (1-2):9-10 Br. J. Cancer