Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma.
Linnik, I V Scott, M L J Holliday, K F Woodhouse, N l Waterton, J C O'Connor, James P B Barjat, H Liess, C Ulloa, J Young, H
Linnik, I V
Scott, M L J
Holliday, K F
Woodhouse, N l
Waterton, J C
O'Connor, James P B
Barjat, H
Liess, C
Ulloa, J
Young, H
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Abstract
There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measurements of tumor hypoxia in a murine glioma xenograft and demonstrated technique translation in human glioblastoma multiforme.
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Date
2014-05
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Article
Citation
Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma. 2014, 71 (5):1854-62 Magn Reson Med