Observations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia.
Rankin, E M Jones, D M Lawston, F G Kane, R J Scarffe, J Howard
Rankin, E M
Jones, D M
Lawston, F G
Kane, R J
Scarffe, J Howard
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Abstract
In a retrospective study we have compared the toxic side effects related to the use of two antibiotic regimens in the treatment of febrile episodes in neutropenic, leukaemic patients undergoing first remission-induction. Nephrotoxicity was more severe in the gentamicin-mezlocillin (G/M) group: four patients developed oliguric renal failure and two others showed rises in the serum creatinine of more than 0.03 mmol/l. One of the two patients in the gentamicin-ticarcillin (G/T) group who showed nephrotoxicity developed renal failure. Ototoxicity and skin rashes were more commonly observed with G/M than with G/T, and the differences were statistically significant for both ototoxicity (P = 0.0004) and drug rashes (P = 0.02). The cause of the observed differences in toxicity has not been identified.
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Date
1984-10
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Citation
Observations on the toxicity of the combination of gentamicin and mezlocillin in the treatment of patients with acute leukaemia. 1984, 14 (4):411-21 J Antimicrob Chemother