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Robust, universal biomarker assay to detect senescent cells in biological specimens.
Evangelou, K Lougiakis, N Rizou, S Kotsinas, A Kletsas, D Muñoz-Espín, D Kastrinakis, N Pouli, N Marakos, P Townsend, Paul A
Evangelou, K
Lougiakis, N
Rizou, S
Kotsinas, A
Kletsas, D
Muñoz-Espín, D
Kastrinakis, N
Pouli, N
Marakos, P
Townsend, Paul A
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Abstract
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally applicable to assess senescence in biomedicine, from cancer research to gerontology.
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2017-02
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Robust, universal biomarker assay to detect senescent cells in biological specimens. 2017, 16(1):192-197 Aging Cell