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Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma.
Propper, D ; Jones, K ; Anthoney, D ; Mansoor, Was ; Ford, D ; Eatock, M ; Agarwal, R ; Inatani, M ; Saito, T ; Abe, M ... show 1 more
Propper, D
Jones, K
Anthoney, D
Mansoor, Was
Ford, D
Eatock, M
Agarwal, R
Inatani, M
Saito, T
Abe, M
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Abstract
TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven active in oesophago-gastric adenocarcinomas, in this phase II study we assessed the efficacy and safety of TP300 in patients with gastric or gastro-oesophageal junction (GOJ) adenocarcinomas.
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2016-10-10
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Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma. 2016, 16 (1):779 BMC Cancer