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Metastasis and oxidative stress: are antioxidants a metabolic driver of progression?
Peiris-Pagès, Maria Martinez-Outschoorn, U Sotgia, Federica Lisanti, Michael P
Peiris-Pagès, Maria
Martinez-Outschoorn, U
Sotgia, Federica
Lisanti, Michael P
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Abstract
The role of reactive oxygen species (ROS) and antioxidants in cancer is controversial because of their context-dependent ability to promote or suppress tumorigenesis. Piskounova et al. (2015) now show that ROS limit distant metastasis: only cells with increased antioxidant capacity are able to succeed in their purpose to metastasize.
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Date
2015-12-01
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Article
Citation
Metastasis and Oxidative Stress: Are Antioxidants a Metabolic Driver of Progression? 2015, 22 (6):956-8 Cell Metab