Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: challenges of daily clinical practice
Fulton, J Lamarca, Angela Nuttall, Christina McCallum, Lynne O'Reilly, D Lalloo, F McNamara, Mairead G Clancy, T
Fulton, J
Lamarca, Angela
Nuttall, Christina
McCallum, Lynne
O'Reilly, D
Lalloo, F
McNamara, Mairead G
Clancy, T
Citations
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Abstract
BACKGROUND:
Identification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family.
AIM:
To assess the referral pathways for genetic consultations in PDAC.
METHODS:
Electronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria.
RESULTS:
Four-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population.
CONCLUSION:
Earlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.
KEYWORDS:
BRCA; Genetic consultation; Genetic counselling; Germline; Pancreatic adenocarcinoma
Description
Date
2019
Publisher
Collections
Keywords
Type
Article
Citation
Fulton A, Lamarca A, Nuttall C, McCallum L, Pihlak R, O'Reilly D, et al. Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: challenges of daily clinical practice. World J Gastrointest Oncol. 2019 Feb 15;11(2):102-16.