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CCR7(+) selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo.
Kueberuwa, Gray Gornall, Hannah Alcantar-Orozco, Erik M Bouvier, Deborah Kapacee, Zainul Abedin Hawkins, Robert E Gilham, David E
Kueberuwa, Gray
Gornall, Hannah
Alcantar-Orozco, Erik M
Bouvier, Deborah
Kapacee, Zainul Abedin
Hawkins, Robert E
Gilham, David E
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Abstract
Adoptive T cell immunotherapy (ATCT) for cancer entails infusing patients with T cells that recognise and destroy tumour cells. Efficient engraftment of T cells and persistence in the circulation correlate with favourable clinical outcomes. T cells of early differentiation possess an increased capacity for proliferation and therefore persistence, using these cells for ATCT could therefore lead to improved clinical outcomes.
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2017
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CCR7(+) selected gene-modified T cells maintain a central memory phenotype and display enhanced persistence in peripheral blood in vivo. 2017, 5:14 J Immunother Cancer