Tumor infiltrating regulatory T cells: tractable targets for immunotherapy.
Khan, A R Dovedi, Simon J Wilkinson, R W Pritchard, D I
Khan, A R
Dovedi, Simon J
Wilkinson, R W
Pritchard, D I
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Abstract
Several studies have linked tumor-infiltration by regulatory T cells with poor patient outcome. Targeting the mechanisms by which regulatory T cells traffic to and persist in the tumor may circumvent tumor immune-escape by de-restricting T cell-mediated cytotoxicity. In this review, we describe the principle axes that govern regulatory T cell migration and the mechanisms that underpin their immunosuppressive activity in cancer. Inhibiting either the migration or function of regulatory T cells may enhance host-anti-cancer immune responses and as such are attractive and tractable targets for therapeutic intervention.
Description
Date
2010-10
Publisher
Collections
Keywords
Regulatory Tumour Cells
Tumour
CTLA-4
GITR
Tumour
CTLA-4
GITR
Type
Article
Citation
Tumor infiltrating regulatory T cells: tractable targets for immunotherapy. 2010, 29 (5):461-84 Int Rev Immunol