Loading...
Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic
Harvie, Michelle N French, David P Pegington, Mary Lombardelli, C. Krizak, S. Sellers, K. Barrett, E. Evans, D Gareth R Cutress, R. Wilding Rgn, A.
Harvie, Michelle N
French, David P
Pegington, Mary
Lombardelli, C.
Krizak, S.
Sellers, K.
Barrett, E.
Evans, D Gareth R
Cutress, R.
Wilding Rgn, A.
Citations
Altmetric:
Abstract
Background: Overweight and obesity are common amongst women attending breast cancer Family History, Risk and Prevention Clinics (FHRPCs). Overweight increases risk of breast cancer (BC) and conditions including1 cardiovascular disease (CVD) and type-2 diabetes (T2D). Clinics provide written health behaviour advice with is likely to have minimal effects. We assessed efficacy of two remotely delivered weight loss programmes vs. written advice.
Method: 210 women with overweight or obesity attending three UK FHRPCs were randomised to either a BC prevention programme (BCPP) framed to reduce risk of BC (n = 86), a multiple disease prevention programme (MDPP) framed to reduce risk of BC, CVD and T2D (n = 87), or written advice (n = 37). Change in weight and health behaviours were assessed at 12-months.
Results: Weight loss at 12 months was -6.3% (-8.2, -4.5) in BCPP, -6.0% (-7.9, -4.2) in MDPP and -3.3% (-6.2, -0.5) in the written group (p = 0.451 across groups). The percentage losing ≥10% weight in these groups were respectively 34%, 23% and 14% (p = 0.038 across groups).
Discussion: BCPP and MDPP programmes resulted in more women achieving ≥10% weight loss, but no evidence of additional benefits of MDPP. A multicentre RCT to test the BCPP across UK FHRPCs is warranted.
Description
Date
2023
Publisher
Collections
Files
Keywords
Type
Article
Citation
Harvie M, French DP, Pegington M, Lombardelli C, Krizak S, Sellers K, et al. Randomised controlled trial of breast cancer and multiple disease prevention weight loss programmes vs written advice amongst women attending a breast cancer family history clinic. British journal of cancer. 2023 Feb 25:1-11. PubMed PMID: 36841908. Pubmed Central PMCID: PMC9961304 of an investigator-led Collaborative Research Agreement between SECA GmbH & Co. KG. (Hamburg, Germany), UHS and the University of Southampton. Also institutional research funding by Astra Zeneca (unrelated to this study). The other authors declare no competing interests. Epub 2023/02/26. eng.