Bioavailability of ifosfamide in patients with bronchial carcinoma.
Cerny, T Margison, Jennifer M Thatcher, Nick Wilkinson, Peter M
Cerny, T
Margison, Jennifer M
Thatcher, Nick
Wilkinson, Peter M
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Abstract
The pharmacokinetics of ifosfamide (I) were determined in ten patients with bronchogenic carcinoma. In seven patients, doses of 1 and 2 g (I) were given both as a bolus orally and later intravenously and were well tolerated. A further three patients received 5 g (I) as a single oral dose but in two this produced reversible CNS toxicity and severe vomiting. The area under the curve (AUC, microgram . h . l-1) for the 1-g dose was the same following oral and i.v. treatment and this was also true for the 2-g doses. There was a proportionate increase in the AUC for the 5-g oral dose, indicating 100% bioavailability at all three dose levels. We conclude that doses up to 2 g by mouth represent a well-tolerated alternative route of administration.
Description
Date
1986
Publisher
Collections
Keywords
Lung Cancer
Type
Article
Citation
Bioavailability of ifosfamide in patients with bronchial carcinoma. 1986, 18 (3):261-4 Cancer Chemother. Pharmacol.