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The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study.
Nordsmark, Marianne Loncaster, Juliette A Aquino-Parsons, Christina Chou, Shu-Chuan Gebski, Val West, Catharine M L Lindegaard, Jacob C Havsteen, Hanne Davidson, Susan E Hunter, Robin D
Nordsmark, Marianne
Loncaster, Juliette A
Aquino-Parsons, Christina
Chou, Shu-Chuan
Gebski, Val
West, Catharine M L
Lindegaard, Jacob C
Havsteen, Hanne
Davidson, Susan E
Hunter, Robin D
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Abstract
BACKGROUND AND PURPOSE: Hypoxia adversely affects treatment outcome in human uterine cervical cancer. Here, we present the results of a prospective international multi-centre study evaluating the prognostic value of pre-treatment tumour oxygen partial pressure (pO(2)) and the hypoxia marker pimonidazole (pimo). MATERIALS AND METHODS: One hundred and twenty-seven patients with primary cervix cancer were entered. Pre-treatment tumour pO(2) measurements were obtained, and reported by the median tumour pO(2), the fraction of pO(2) values
Description
Date
2006-08
Publisher
Keywords
Uterine Cervical Cancer
Type
Article
Citation
The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study. 2006, 80 (2):123-31 Radiother Oncol