Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model.
Agur, Z Kirnasovsky, O U Vasserman, G Tencer-Hershkowicz, L Kogan, Y Harrison, Hannah Lamb, Rebecca Clarke, Robert B
Agur, Z
Kirnasovsky, O U
Vasserman, G
Tencer-Hershkowicz, L
Kogan, Y
Harrison, Hannah
Lamb, Rebecca
Clarke, Robert B
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Abstract
Modulation of cellular signaling pathways can change the replication/differentiation balance in cancer stem cells (CSCs), thus affecting tumor growth and recurrence. Analysis of a simple, experimentally verified, mathematical model suggests that this balance is maintained by quorum sensing (QS).
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Date
2011
Publisher
Collections
Keywords
Type
Article
Citation
Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model. 2011, 6 (9):e24225 PLoS ONE