Residual skin injury after repeated irradiation: differences observed using healing, macrocolony, and microcolony endpoints.
Chen, Fu-Du Hendry, Jolyon H
Chen, Fu-Du
Hendry, Jolyon H
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Abstract
Following three repeated tolerance doses to mouse tail skin, residual injury was characterized by a 35% reduction in the iso-effective dose compared to age-matched controls, using healing or macrocolony endpoints. In contrast, the reduction was only 9%, measured using microcolony formation. The colony data showed that the reduction was a constant dose, not a dose-modifying effect. The residual injury is interpreted as due to a reduced density of microcolony-forming cells in the epidermis, and these are less capable of macrocolony formation and hence of re-epithelialization in the repeatedly-irradiated epidermis.
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1988-10
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Residual skin injury after repeated irradiation: differences observed using healing, macrocolony, and microcolony endpoints. 1988, 15 (4):943-8 Int. J. Radiat. Oncol. Biol. Phys.