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SAMHD1 sheds moonlight on DNA double-strand break repair.
Cabello-Lobato, Maria J Wang, Siyue Schmidt, Christine K
Cabello-Lobato, Maria J
Wang, Siyue
Schmidt, Christine K
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Abstract
SAMHD1 (sterile α motif and histidine (H) aspartate (D) domain-containing protein 1) is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks (DSBs) by promoting recruitment of C-terminal binding protein interacting protein (CTIP), a DNA-end resection factor, to damaged DNA. These findings could benefit anticancer treatment.
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2017-09-29
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SAMHD1 sheds moonlight on DNA double-strand break repair. 2017, Trends Genet.