Tissue-resident FOLR2(+) macrophages associate with CD8(+) T cell infiltration in human breast cancer
Ramos, R. N. Missolo-Koussou, Y. Gerber-Ferder, Y. Bromley, Christian P Bugatti, M. Nunez, N. G. Boari, J. T. Richer, W. Menger, L. Denizeau, J.
Ramos, R. N.
Missolo-Koussou, Y.
Gerber-Ferder, Y.
Bromley, Christian P
Bugatti, M.
Nunez, N. G.
Boari, J. T.
Richer, W.
Menger, L.
Denizeau, J.
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Abstract
Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2+ macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8+ T cells. FOLR2+ macrophages efficiently prime effector CD8+ T cells ex vivo. The density of FOLR2+ macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.
Authors
Ramos, R. N.
Missolo-Koussou, Y.
Gerber-Ferder, Y.
Bromley, Christian P
Bugatti, M.
Nunez, N. G.
Boari, J. T.
Richer, W.
Menger, L.
Denizeau, J.
Sedlik, C.
Caudana, P.
Kotsias, F.
Niborski, L. L.
Viel, S.
Bohec, M.
Lameiras, S.
Baulande, S.
Lesage, L.
Nicolas, A.
Meseure, D.
Vincent-Salomon, A.
Reyal, F.
Dutertre, C. A.
Ginhoux, F.
Vimeux, L.
Donnadieu, E.
Buttard, B.
Galon, J.
Zelenay, Santiago
Vermi, W.
Guermonprez, P.
Piaggio, E.
Helft, J.
Missolo-Koussou, Y.
Gerber-Ferder, Y.
Bromley, Christian P
Bugatti, M.
Nunez, N. G.
Boari, J. T.
Richer, W.
Menger, L.
Denizeau, J.
Sedlik, C.
Caudana, P.
Kotsias, F.
Niborski, L. L.
Viel, S.
Bohec, M.
Lameiras, S.
Baulande, S.
Lesage, L.
Nicolas, A.
Meseure, D.
Vincent-Salomon, A.
Reyal, F.
Dutertre, C. A.
Ginhoux, F.
Vimeux, L.
Donnadieu, E.
Buttard, B.
Galon, J.
Zelenay, Santiago
Vermi, W.
Guermonprez, P.
Piaggio, E.
Helft, J.
Description
Date
2022
Publisher
Collections
Keywords
Type
Article
Citation
Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, et al. Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer. Vol. 185, Cell. Elsevier BV; 2022. p. 1189-1207.e25.