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The reduction of anti-tumour diaziridinyl benzoquinones.

Butler, John
; 
Hoey, Brigid M
; 
Lea, J S
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Abstract
The properties of the semiquinone radicals produced for 2,5-bis(carboethoxyamino)-3,6-diaziridinyl-1,4-benzoquinone (AZQ) and 2,5-bis(2-hydroxyethylamino)-3,6-diaziridinyl-1,4-benzoquinone (BZQ), have been investigated. AZQ semiquinone radicals can be produced from the reduction of AZQ by superoxide radicals, whereas BZQ semiquinone radicals are unstable in the presence of oxygen. The one-electron reduction potentials of the couples Q/Q-. at pH 7.0 were determined as -70 +/- 10 mV for AZQ and -376 +/- 15 mV for BZQ. The difference in these potentials is explained. As a consequence of ESR studies on the enzymatically produced radicals, we have considered the factors which determine the detection of ESR signals for reduced quinones produced in a biological system.
Authors
Butler, John
Hoey, Brigid M
Lea, J S
Affiliation
Department of Biophysical Chemistry, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX, U.K.
Description
Date
1987-08-13
Publisher
Collections
All Paterson Institute for Cancer Research
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Keywords
Anticancerous Agents
Type
Article
Citation
The reduction of anti-tumour diaziridinyl benzoquinones. 1987, 925 (2):144-9 Biochim Biophys Acta
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/114969
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