Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood.
Hartley, Ann L Birch, Jillian M Blair, Val Jones, P M Gattamaneni, Rao Kelsey, Anna M
Hartley, Ann L
Birch, Jillian M
Blair, Val
Jones, P M
Gattamaneni, Rao
Kelsey, Anna M
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Abstract
Eight second malignant tumours developed in a population-based series of 218 patients diagnosed with renal tumours in childhood: renal cell carcinoma of the contralateral kidney, hepatocellular carcinoma, Hodgkin's disease, and 4 basal cell and 1 squamous cell carcinomas of skin. Excess risk of developing a second malignancy (excluding skin carcinomas but including a registrable spinal neurofibroma) was 14.7 (95% CI 4.0-37.7, P = 0.0003) for Wilms' tumour patients. Cumulative incidence of second malignant neoplasms (excluding skin carcinoma) was zero at 10 years, 5.0% at 20 years, and 10.2% at 30 years. The most common second neoplasms seen were benign osseous/chondromatous tumours and 4 of the 7 Wilms' tumour patients with malignant tumours had previous or synchronous tumours of this kind. Development of bony exostoses may be a marker for those patients at particularly high risk of subsequent malignancy.
Description
Date
1994
Publisher
Collections
Keywords
Kidney Cancer
Second Primary Cancer
Wilms Tumour
Second Primary Cancer
Wilms Tumour
Type
Article
Citation
Second primary neoplasms in a population-based series of patients diagnosed with renal tumours in childhood. 1994, 22 (5):318-24 Med. Pediatr. Oncol.