Primary malignant lymphoma of the thyroid: a clinicopathological analysis.
Logue, John P Hale, R J Stewart, Alan L Duthie, M B Banerjee, Saumitra S
Logue, John P
Hale, R J
Stewart, Alan L
Duthie, M B
Banerjee, Saumitra S
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Abstract
A retrospective analysis of 70 patients with primary malignant lymphoma of the thyroid treated at this institute between 1965-1983 has been conducted. The clinicopathological features and prognostic factors have been studied. The mean age was 67.5 years and there was a marked female:male ratio of 8:1. A total of 32 (45.7%) Stage IE and 38 (54.3%) Stage IIE patients were identified. In 64 cases histological material was reviewed and classified employing the Kiel classification. All the tumors were of B cell lineage and the majority were follicle center cell type. A biopsy only was performed in 27 patients, lobectomy in 11 patients, subtotal thyroidectomy in 27 and macroscopic thyroidectomy in 5 patients. All patients were treated with radiotherapy. The overall 5-year survival was 42%, with 63% for Stage IE and 27% for Stage IIE. The corrected overall 5-year survival was 49% with 68% for Stage IE and 36% for Stage IIE. The corresponding overall relapse free survival was 42% with 60% for Stage IE, and 31% for Stage IIE. Factors of prognostic significance for relapse and survival were stage, radiotherapy dose, stridor, retrosternal extension and fixation.
Description
Date
1992
Publisher
Collections
Keywords
Thyroid Cancer
Type
Article
Citation
Primary malignant lymphoma of the thyroid: a clinicopathological analysis. 1992, 22 (5):929-33 Int J Radiat Oncol Biol Phys