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Histopathology in the prediction of relapse of patients with stage I testicular teratoma treated by orchidectomy alone.
Freedman, L Parkinson, M Jones, W Oliver, R Peckham, M Read, G Newlands, E Williams, C
Freedman, L
Parkinson, M
Jones, W
Oliver, R
Peckham, M
Read, G
Newlands, E
Williams, C
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Abstract
259 patients with stage I non-seminomatous germ-cell testicular teratoma who were treated by orchidectomy alone and monitored at one often centres in the United Kingdom were followed for a median of 30 months. 62 of the 70 relapses occurred in the first 18 months after orchidectomy. The 2-year relapse-free rate was 74%, falling to 68% at 4 years. Histological sections from 233 of the orchidectomy specimens were reviewed centrally. Four features independently predicted relapses: invasion of testicular veins, invasion of testicular lymphatics, absence of yolk-sac elements, and presence of undifferentiated tumour. An index, based on the number of these features observed, identified a high-risk subgroup of 55 patients who had a 42% relapse-free rate at 2 years.
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Description
Date
1987-08-08
Publisher
Collections
Keywords
Cancer Staging
Testicular Cancer
Testicular Cancer
Type
Article
Citation
Histopathology in the prediction of relapse of patients with stage I testicular teratoma treated by orchidectomy alone. 1987, 2 (8554):294-8 Lancet