Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation.
Eyden, Brian P Dardick, I Bishop, Paul
Eyden, Brian P
Dardick, I
Bishop, Paul
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Abstract
A hyaline/eosinophilic cytoplasmic inclusion is described in a metastatic tumor occurring in the omentum and bowel of a 32-year-old white woman. The tumor was essentially of round cell type; was positive for cytokeratin, actin, and S-100 protein by immunohistochemistry; and showed desmosomes (maculae adherentes), tonofibrils, modestly developed myofilaments with focal densities, and a basal lamina by electron microscopy. It was therefore interpreted as showing myoepithelial differentiation. Nearly all cells possessed a large, rounded cytoplasmic inclusion that was architecturally unusual, consisting of intermediate filaments intermingled with lattices of fine filaments. The inclusions exhibited an additionally unusual immunohistochemical staining for both cytokeratin and actin. A comparison with cases described in the literature is made.
Authors
Description
Date
1991
Publisher
Collections
Keywords
Intestinal Cancer
Cancer Metastasis
Cancer Metastasis
Type
Article
Citation
Filamentous inclusions of unusual composition and architecture in a metastatic tumor showing myoepithelial differentiation. 15 (6):663-70 Ultrastruct Pathol