Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway.
Peiró, C Romacho, T Azcutia, V Villalobos, L Fernández, E Bolaños, J Moncada, Salvador Sánchez-Ferrer, C
Peiró, C
Romacho, T
Azcutia, V
Villalobos, L
Fernández, E
Bolaños, J
Moncada, Salvador
Sánchez-Ferrer, C
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Abstract
Hyperglycemia is acknowledged as a pro-inflammatory condition and a major cause of vascular damage. Nevertheless, we have previously described that high glucose only promotes inflammation in human vascular cells previously primed with pro-inflammatory stimuli, such as the cytokine interleukin (IL)1β. Here, we aimed to identify the cellular mechanisms by which high glucose exacerbates the vascular inflammation induced by IL1β.
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Date
2016-06-01
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Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway. 2016, 15:82 Cardiovasc Diabetol