An EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry?
Salman, W D Eyden, Brian P Shelton, D Howat, A Al-Dawoud, A Twaij, Z
Salman, W D
Eyden, Brian P
Shelton, D
Howat, A
Al-Dawoud, A
Twaij, Z
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Abstract
Histopathologists in the current environment of medical negligence and litigation are more likely to use immunohistochemical investigations in their day-to-day practice to support their diagnosis and avoid future litigation. The caveat is that relying on immunohistochemistry is a double-edged sword and pathologists should be familiar with its limitations. We present a case of primary malignant peritoneal mesothelioma with an unusual immunohistochemical profile-desmin positive, EMA negative-and wish to highlight the importance of cautiously interpreting immunohistochemistry profiles when they do not fit the clinical history and histological appearance.
Description
Date
2009-07
Publisher
Collections
Keywords
Peritoneal Cancer
Biological Tumour Markers
Biological Tumour Markers
Type
Article
Citation
An EMA negative, desmin positive malignant mesothelioma: limitations of immunohistochemistry? 2009, 62 (7):651-2 J. Clin. Pathol.