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Case report: all that glitters is not cancer; perihepatic hibernoma with fluctuating FDG uptake on PET/CT
Ramzan, Amaila Chander, Amarjot Westwood, Thomas Elias, Mark Manoharan, Prakash
Ramzan, Amaila
Chander, Amarjot
Westwood, Thomas
Elias, Mark
Manoharan, Prakash
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Abstract
Hibernomas are rare brown fat tumors that garnered attention in the literature with the increasing use of [(18)F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography ([(18)F] FDG PET/CT) for the staging workup and follow-up of solid malignancies. Despite being benign tumors, they exhibit high metabolic activity due to their thermogenic nature, leading to significant radiotracer uptake on functional imaging. This can pose a challenge in differentiating them from the malignant lesions, especially the fat-containing malignancies such as liposarcoma. Hibernomas are typically found in the thigh, shoulder, back, and neck. Here, we present a unique case of Hibernoma in a patient undergoing PET/CT for melanoma follow-up in an unusual perihepatic location. To the best of the authors' knowledge, this represents the first reported case of a perihepatic hibernoma in the literature. The report also offers a literature review on hibernomas, including the influence of ambient temperature on their metabolism, diagnostic challenges, management strategies, and reports of hibernomas detected on functional imaging with a range of radiotracers. These observations could serve as a valuable clue in identifying hibernomas, potentially aiding in avoiding unnecessary biopsies or resections.
Description
Date
2024
Publisher
Collections
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Type
Article
Citation
Ramzan A, Chander A, Westwood T, Elias M, Manoharan P. Case Report: All that glitters is not cancer; perihepatic hibernoma with fluctuating FDG uptake on PET/CT. Frontiers in nuclear medicine (Lausanne, Switzerland). 2024;4:1477467. PubMed PMID: 39507633. Pubmed Central PMCID: PMC11537942. Epub 2024/11/12. eng.