Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia.
Bontkes, Hetty J De Gruijl, Tanja D Bijl, Astrid Verheijen, René H Meijer, Chris J L M Scheper, Rik J Stern, Peter L Burns, Julie E Maitland, Norman J Walboomers, Jan M
Bontkes, Hetty J
De Gruijl, Tanja D
Bijl, Astrid
Verheijen, René H
Meijer, Chris J L M
Scheper, Rik J
Stern, Peter L
Burns, Julie E
Maitland, Norman J
Walboomers, Jan M
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Abstract
T-cell-mediated immune responses against mucosal oncogenic types of human papillomaviruses (HPV) are thought to play a role in the control of the virus infection and its associated cervical lesions. The in vitro production of interleukin-2 by T-helper (Th) cells in response to the C-terminal and N-terminal domains of the HPV-16 E2 protein was determined in 74 women with cytological evidence of premalignant cervical epithelial neoplasia who participated in a non-intervention follow-up (FU) study. Cross-sectional analysis at the end of FU showed that Th cell responses against the C-terminal domain were associated with evidence of previous or present HPV-16 infection as compared to patients with no evidence of any HPV infection (18.9% versus 0%, P = 0.039). Th cell responses against the N-terminal domain were not associated with evidence of HPV-16 infection. No association with disease outcome was observed with Th cell responses against either of the E2 protein domains. However, longitudinal analysis revealed that Th cell responses against the C-terminal domain frequently occur at the time of virus clearance. Whether these responses are responsible for the clearance of the virus is not known.
Description
Date
1999-09
Publisher
Collections
Keywords
Uterine Cervical Cancer
Type
Article
Citation
Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia. 1999, 80 ( Pt 9):2453-9 J. Gen. Virol.