A pilot study assessing the prognostic value of CK18 and nDNA biomarkers in severe sepsis patients.
Moore, David Greystoke, Alastair Butt, F Wurthner, J Growcott, J Hughes, A
Moore, David
Greystoke, Alastair
Butt, F
Wurthner, J
Growcott, J
Hughes, A
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Abstract
Severe sepsis and septic shock have posed significant treatment challenges for many years. Recently, a number of circulating apoptosis biomarkers have emerged, such as full-length and caspase-cleaved cytokeratin 18 (CK18) and nucleosomal DNA (nDNA), that may be predictive of likely outcome. This non-interventional study aimed to assess the ability of enzyme-linked immunosorbent assays (ELISAs) for these biomarkers to provide clinically useful information to guide the management of sepsis.
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Date
2012-03-01
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Article
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A pilot study assessing the prognostic value of CK18 and nDNA biomarkers in severe sepsis patients. 2012, 32 (3):179-87 Clin Drug Investig