Generation of a contig comprising YACs and BACs within chromosome region 1p13.1.
Brintnell, Bill Hey, Yvonne Jones, David Hoggard, Nigel James, Louise A Varley, Jennifer
Brintnell, Bill
Hey, Yvonne
Jones, David
Hoggard, Nigel
James, Louise A
Varley, Jennifer
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Abstract
Chromosome region 1p13 is known to show loss of heterozygosity (LOH) in a number of human tumor types, including breast. We have generated a contig comprising YACs and BACs spanning part of 1p13.1 which includes the smallest region of overlapping loss identified in our earlier studies. The contig is anchored to the genetic map by a number of microsatellite markers, and by the use of CEPH YACs. We have excluded a number of candidate genes from this region, and we have oriented the contig with respect to the centromere and a number of other genes and markers on 1p13. This resource will be valuable in mapping the target for LOH in breast and other tumors, and may also be useful for the genetic analysis of other genes or diseases known to map to this region.
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Date
1997-03
Publisher
Collections
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Article
Citation
Generation of a contig comprising YACs and BACs within chromosome region 1p13.1. 1997, 23 (2):153-7 Somat. Cell Mol. Genet.