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Final results of the large-scale multinational trial PROFILE 1005: efficacy and safety of crizotinib in previously treated patients with advanced/metastatic ALK-positive non-small-cell lung cancer.
Blackhall, Fiona H ; Ross Camidge, D ; Shaw, A ; Soria, J ; Solomon, B ; Mok, T ; Hirsh, V ; Jänne, P ; Shi, Y ; Yang, P ... show 9 more
Blackhall, Fiona H
Ross Camidge, D
Shaw, A
Soria, J
Solomon, B
Mok, T
Hirsh, V
Jänne, P
Shi, Y
Yang, P
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Abstract
Crizotinib is a potent, orally administered tyrosine kinase inhibitor approved for the treatment of anaplastic lymphoma kinase (ALK)-positive advanced non-small-cell lung cancer (NSCLC). We report final results from PROFILE 1005, the largest clinical trial to date for an ALK inhibitor in ALK-positive NSCLC.
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Date
2017
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Final results of the large-scale multinational trial PROFILE 1005: efficacy and safety of crizotinib in previously treated patients with advanced/metastatic ALK-positive non-small-cell lung cancer. 2017, 2 (3):e000219 ESMO Open