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An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment?
Chong, MY Lorimer, CF Mehta, Shaveta Ibrahim, Ehab Brock, J McBain, Catherine A McLoone, P Chalmers, AJ
Chong, MY
Lorimer, CF
Mehta, Shaveta
Ibrahim, Ehab
Brock, J
McBain, Catherine A
McLoone, P
Chalmers, AJ
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Abstract
Aim: We investigated uptake of short-course chemo-radiotherapy and compared outcomes with other treatment schedules in elderly patients with glioblastoma (GBM). Methods: Patients aged 65 or over with a diagnosis of GBM were identified from an 18-month period from three centers in the UK. The primary end point of this study was overall survival from the date of diagnosis. Results: The analysis included 210 patients. Overall median survival was 5.0 months. Approximately 31.9% of patients received combined chemoradiation; multivariate analysis showed that patients who received standard chemoradiation were at a reduced risk of death than those receiving hypofractionated chemoradiation. Discussion: In this retrospective study, patients treated with standard chemoradiation experienced better outcomes than patients receiving hypofractionated chemoradiation. Patient selection likely contributed to these findings.
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2019
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Chong MY, Lorimer CF, Mehta S, Ibrahim E, Brock J, McBain C, et al. An audit of the management of elderly patients with glioblastoma in the UK: have recent trial results changed treatment? CNS Oncol. 2019;8(4):CNS47.