The interaction of chalcones with tubulin.
Lawrence, Nicholas J McGown, Alan T Ducki, Sylvie W Hadfield, John A
Lawrence, Nicholas J
McGown, Alan T
Ducki, Sylvie W
Hadfield, John A
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Abstract
The chalcone 3,4,3',4',5'-pentamethoxychalcone is a potent cytotoxic agent. A series of chalcones and (E)-4-(4'-hydroxyphenyl)but-3-en-2-one were prepared and assessed for their ability to inhibit cell growth in vitro. The cytotoxicity correlates with their ability to bind to tubulin as measured by immunofluorescence, cell cycle analysis and disruption of microtubule assembly. Some of the chalcones were shown to bind to the type II oestrogen receptor.
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Date
2000-04
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Article
Citation
The interaction of chalcones with tubulin. 2000, 15 (2):135-41 Anticancer Drug Des.