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The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects?
Aruoma, O I Wasil, M Halliwell, B Hoey, Brigid M Butler, John
Aruoma, O I
Wasil, M
Halliwell, B
Hoey, Brigid M
Butler, John
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Abstract
Sulphasalazine (Salazopyrin) and its metabolites sulphapyridine and 5-aminosalicylate are powerful scavengers of the hydroxyl radical, determined by pulse radiolysis and confirmed by assays based on deoxyribose degradation by hydroxyl radicals. 5-Aminosalicylate can also protect alpha 1-antiprotease against attack by the myeloperoxidase-derived oxidant hypochlorous acid. The ability to scavenge oxidants produced at sites of inflammation may contribute to the anti-inflammatory action of sulphasalazine and its metabolites.
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Date
1987-11-01
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Article
Citation
The scavenging of oxidants by sulphasalazine and its metabolites. A possible contribution to their anti-inflammatory effects? 1987, 36 (21):3739-42 Biochem Pharmacol