Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix.
Donaldson, S B Buckley, David L O'Connor, James P B Davidson, Susan E Carrington, Bernadette M Jones, Andrew P West, Catharine M L
Donaldson, S B
Buckley, David L
O'Connor, James P B
Davidson, Susan E
Carrington, Bernadette M
Jones, Andrew P
West, Catharine M L
Citations
Altmetric:
Abstract
Background:There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods:This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E(F)) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results:Tumours with high E(F) had a significantly poorer probability of DFS than those with low E(F) (P=0.011).Interpretation:E(F) is a simple imaging biomarker that should be studied further in a multi-centre setting.
Description
Date
2010-01-05
Publisher
Collections
Keywords
Cancer Metastasis
Cancer Recurrence
Residual Cancer
Uterine Cervical Cancer
Cancer Recurrence
Residual Cancer
Uterine Cervical Cancer
Type
Article
Citation
Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix. 2010, 102 (1):23-6 Br. J. Cancer