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Mapping of gene loci in the Q13-Q15 region of chromosome 12.

Mitchell, Erika L D
; 
White, Gavin R M
; 
Santibanez-Koref, Mauro F
; 
Varley, Jennifer
; 
Heighway, Jim
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Abstract
The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.
Authors
Mitchell, Erika L D
White, Gavin R M
Santibanez-Koref, Mauro F
Varley, Jennifer
Heighway, Jim
Affiliation
Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.
Description
Date
1995-06
Publisher
Collections
All Paterson Institute for Cancer Research
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Keywords
Type
Article
Citation
Mapping of gene loci in the Q13-Q15 region of chromosome 12. 1995, 3 (4):261-2 Chromosome Res.
Journal Title
Journal ISSN
Volume Title
URI
http://hdl.handle.net/10541/97944
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