The MOMENTUM study, an international registry of patients treated on an MR-linac: 9-month experience
Van Otterloo, S. D. Blezer, E. L. A. Fuller, C. D. Sahgal, A. Van der Heide, U. A. Christodouleas, J. P. Akhiat, H. Mook, S. Intven, M. P. W.
Van Otterloo, S. D.
Blezer, E. L. A.
Fuller, C. D.
Sahgal, A.
Van der Heide, U. A.
Christodouleas, J. P.
Akhiat, H.
Mook, S.
Intven, M. P. W.
Citations
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Abstract
Purpose or Objective
On February first 2019, the Multi-OutcoMe EvaluatioN of
radiation Therapy Using the MR-linac study (MOMENTUM)
opened for accrual. MOMENTUM is a prospective,
international registry which facilitates technical
development, clinical evaluation and evidence-based
implementation of MRI guided Radiotherapy using the
Unity MR-linac (Elekta AB). The MR-linac integrates a
linear accelerator with a 1.5T diagnostic quality MRI and
an online adaptive workflow. Here we present our 9-month
experience of the MOMENTUM study.
Material and Methods
MOMENTUM study is an international academic-industrialpartnership
between seven hospitals and industry partner
Elekta (Elekta AB, Stockholm, Sweden). After initiation of
the study, all patients treated with the MR-linac were
eligible for inclusion. Pseudonymized clinical and technical
patient data are captured at set time intervals until 24
months after treatment with the MR-linac. Clinical data,
stored in an Openclinica database, include demographics,
tumor characteristics, treatment details, toxicity, disease
recurrence and survival data. Technical data, i.e. all the
data generated and used by the machine before, during
and after treatment is stored on a cloud-based platform.
All participants in MOMENTUM provide informed consent
for use of their data by the academic consortium partners
and for data sharing with the industry partner except for
Dutch patients. In The Netherlands patients can choose
whether they want to share their data with the industry
partner. Furthermore, all participants are asked to provide
additional consent for collection of patient reported outcomes (PRO) and additional MRI scans on the MRlinac.
Results
Between February and October 2019, the study opened in
all seven institutes, and until now, 200 patients have
provided informed consent for participation in
MOMENTUM. At time of writing, we accrued 127 patients
with known information on tumor location with a median
age of 66 years. 71% (n=90) of 127 patients were male.
Most patients were treated for oligometastases (N=42),
rectal cancer (N=21), or prostate cancer (N=12) (Figure 1).
95 patients had complete treatment data with a mean
number of fraction per patients of four to 33. For 199
participants, preferences regarding additional data
collection and data sharing with the industry were known.
197 (99%) of 199 participants shared data with industry
partner Elekta, 80% (N=159) of participants consented to
additional research MRIs, and 67% (N=133) of participants
chose to collect additional PROs Conclusion
The MOMENTUM study, an international multi-institutional
registry, opened successfully at several sites and accrued
200 patients treated with the Unity MR-linac. Participants
were treated with a mean number of fraction of four to 33
per patient. MOMENTUM contributes to optimal collection
and usage of data of patients enabling the evidence-based
implementation of the MR-linac.
Authors
Van Otterloo, S. D.
Blezer, E. L. A.
Fuller, C. D.
Faivre-Finn, Corinne
Sahgal, A.
Van der Heide, U. A.
Christodouleas, J. P.
Akhiat, H.
Mook, S.
Intven, M. P. W.
Van Triest, B.
Tree, A. C.
Kirby, A. M.
Lalondrelle, S.
Schultz, C.
Erickson, B.
Emma, H.
Nowee, M. E.
Hafeez, S.
Oelfke, U.
Tersteeg, R. H. A.
Eggert, D.
Hall, W. A
Verkooijen, H. M.
Blezer, E. L. A.
Fuller, C. D.
Faivre-Finn, Corinne
Sahgal, A.
Van der Heide, U. A.
Christodouleas, J. P.
Akhiat, H.
Mook, S.
Intven, M. P. W.
Van Triest, B.
Tree, A. C.
Kirby, A. M.
Lalondrelle, S.
Schultz, C.
Erickson, B.
Emma, H.
Nowee, M. E.
Hafeez, S.
Oelfke, U.
Tersteeg, R. H. A.
Eggert, D.
Hall, W. A
Verkooijen, H. M.
Description
Date
2020
Publisher
Collections
Keywords
Type
Meetings and Proceedings
Citation
Van Otterloo SDM, Blezer ELA, Fuller CD, Faivre-Finn C, Sahgal A, Van der Heide UA, et al. PD-0071: The MOMENTUM study, an international registry of patients treated on an MR-linac: 9-month experience. Radiotherapy and Oncology . 2020 Nov;152:S30–1.