Circadian rhythms in the epithelial cells and the pericryptal fibroblast sheath in three different sites in the murine intestinal tract.
Neal, J Valerie Potten, Christopher S
Neal, J Valerie
Potten, Christopher S
Citations
Altmetric:
Abstract
Variations in percentage labelling (LI) and mitotic activity (mitoses per crypt) have been studied over a 24-hr period in the epithelial cells and pericryptal fibroblast sheath (PCFS) of the small intestine, caecum, and colon of the mouse. All three tissues displayed clear, synchronized circadian rhythms in DNA-synthetic activity in both the epithelial cells and PCFS. Peak values were coincident within a tissue, but staggered between tissues. In the epithelial cells, peak mitotic values were found between 3 and 6 hr after the peak LI values. The low level of mitotic activity in the PCFS appeared to be synchronized with the rhythms in the adjacent epithelia. The epithelial cells of the lowest crypt third displayed the clearest circadian rhythms. However, the PCFS cells at all levels produced similar curves. A craniocaudal wave of proliferative activity is proposed.
Authors
Description
Date
1981-11
Publisher
Collections
Keywords
Type
Article
Citation
Circadian rhythms in the epithelial cells and the pericryptal fibroblast sheath in three different sites in the murine intestinal tract. 1981, 14 (6):581-7 Cell Tissue Kinet